I think my title says it all on the latest (not official) HTC TouchFLO 3D 2.6 (or Manila 2.6). It has colors added to the icons, lesser of the Windows Mobile feel and integration of TouchFLO 3D to almost every application (which is nice).
One of the major change is the front screen. It incorporated weather information (like in HTC Hero) and also, for the first time for a TouchFLO3D, to add in icons on the front page. Now, I see a reason of minimizing the clock in older version of TouchFLO3D.
The best part about these icons is that they are not restricted by anything. You can add widgets, program, shortcuts, contacts or whatever into it. I guess HTC thinks that everyone will want to be able to do everything in one single page. Nice.
Changes are also made on the Pictures Tab. Now, you can scroll the pictures in landscape mode with nice animation.
The Albums Tab is also changed. It has now coverflow kind of feel when you rotate the screen to landscape.
There are other changes like the Browser Tab, Contacts Tab, Calendar Tab. You can see it on the Tour video.
Click Here to Watch HTC TouchFLO3D 2.6 Tour Video
If you want to see how the multimedia tabs are changed, click the below link.
Click Here to Watch the Changes on Multimedia Tabs of HTC TouchFLO3D 2.6
Or if you want to skip all and go straight to get the ROM, click the below link.